Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

Author: Muran Mozuru
Country: Pakistan
Language: English (Spanish)
Genre: Personal Growth
Published (Last): 14 August 2018
Pages: 202
PDF File Size: 6.22 Mb
ePub File Size: 5.76 Mb
ISBN: 766-9-24296-409-9
Downloads: 90612
Price: Free* [*Free Regsitration Required]
Uploader: Barr

Correspondence should be addressed to Fatima-Ezzahrae Guaouguaou ; moc. Essential oils are complex molecules containing various and several terpenoids compounds belonging mainly to monoterpene and sesquiterpene chemical groups and presenting different functional groups such as alcohols, phenols, ketone, etc. The exact mechanisms through which such compounds act in their cytotoxicity effect are not well known, but some tentative investigations suggested that these compounds could interrupt the life cycle cell, inducing the apoptosis pathways and inactivating the telomerase [ 6 ].

For the town, see Cotula, Tennessee. Topics Discussed in This Paper. Burtt Cotula reptans Benth. Vogel Cotula filifolia Thunb. Higher concentrations were needed in the case of Salvia verbenaca extracts which showed the weakest cytotoxic effects. The essential oil and the ethyl acetate extract showed moderate cytotoxic effects Cotula vulgaris Levyns Cotula zeyheri Fenzl.

Subscribe to Table of Contents Alerts.

BioMed Research International

Then, solvents of the different obtained extracts were evaporated and the dried residues were used to explore their cytotoxic effect. A potent cytotoxicity was thus observed for the Cotula cinerea hexane extract which inhibited the growth of RD cell line at the lowest IC 50 value However, and despite the widespread use of these plants in Moroccan traditional folk medicine, to the best of our knowledge, no information has been previously reported on the anticancer activity of Moroccan Cotula cinerea and Salvia verbenaca.


From Wikipedia, the free encyclopedia. Traditional forms of medicine, especially the herbal products deployed for centuries in many parts of the world, could be good alternative for scientific investigation due to their attributes against tumor cell lines. Sports Turf Research Institute. According to the World Health Organization, incidence and mortality due to cancer are widely increasing in the world [ 3 ].

Indeed, the explored extracts are complex mixtures containing several phytochemical compounds which could have different biological activities. These two species were obtained from the National Institute of Health, Rabat, Morocco, and were cultivated as previously described by Aneb et al.

The antiproliferative activity of Cotula cinerea essential oil against the Vero tumor cell line could be due to presence of cytotoxic molecules cptula the oil.

Flavonoids from Cotula cinerea Del – Semantic Scholar

Table of Contents Alerts. In the genus was subdivided by George Bentham [5] into three sections. Due to its complex phytochemical composition, it is difficult to define a unique mechanism of its action on the used cell tumor.

In this work we were interested in exploring the potential cytotoxicological effect coula Cotula cinerea and Salvia verbenaca from Morocco.

Cotula cinerea

The genus can only be defined by looking at the corollas of their flowers. Evaluation of the Cytotoxicity Before evaluating the antiproliferative activity, the cellular density of each species was determined using light xotula. Results and Discussion In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca.

Cotula is known to be used in New Zealand as ground cover for bowling greens, playing fields on which the ball-game of bowls is played [6] [7].


Levyns Cotula elongata B. In the case the RD cell line, the lowest IC 50 value The action and mechanism of Cotula cinerea essential oil is very complex involving several targeting pathways as previously reported [ 5 ].

Despite the appreciable advancements and progress made in cancer treatment, it continues to constitute a serious global health problem, especially with the appearance of multidrug resistance cells. An examination of the obtained results showed that the cytotoxic effects of the investigated plants extracts were different according cjnerea the tested cell line with an efficient activity of Cotula cinerea compared to Salvia verbenaca.

The enumeration of cells was made using Malassez cell count. Phillips Cotula pterocarpa DC.

The evaluation of cell viability has been achieved through the use of MTT 3- 4,5-dimethylthiazol-2,5-diphenyl tetrazolium bromide assay. The exact mechanism through which the explored extracts act on each tumor cell line is obviously difficult to highlight. Mouzdahir A Huile essentielle de Santolina africana Jord.

Furthermore, natural products could be as efficient ctula synthetic ones with no or less toxicity and are less expensive than synthetic drugs. Indeed, the antitumor properties of phenolic compounds and flavonoids against several cell lines representing numerous human cell lines have been previously reported [ 6 ]. Oils, Volatile Search for additional papers on this topic. The main constituents of the essential oil are Camphor, Camphene, Alpha-pinene, 3-carene, Thujone, 4-terpineol, Z -betafarnesene and santolinatriene.

Cotula australis Sieber ex Spreng. The obtained results raise then the possibility of a potential use of Cotula cinerea as a source of potent anticancer products.